e-Sports become a part of our modern sport as it has entered our agenda in recent years, its popularity has increased rapidly and its mass of followers consists of young generation has reached a huge budget. In this review, the definition of e-Sport, historical development process, place in the world and our country, the spiritual and physical positive and negative effects on the individuals has been mentioned. Finally, it was mentioned about ergonomic changes and practical exercise suggestions to prevent possible musculoskeletal problems in e-Sport players. Scientific studies about e-Sports in Turkey is limited compared to other countries. With this study, it is aimed to eliminate the lack of Turkish resources related to this field which is developing day by day, to share the findings with the related health professionals and to contribute to the literature.