Pathological gambling is a mental disorder characterized that might cause significant decrements in social, vocational and family life. In this report, addictive gambling behavior, which may be called secondary or iatrogenic, has been reviewed.

Psychoactive substance use disorder can be defined as a chronic illness with an uncontrollable impulsivity to drug use by affecting reward, motivation, memory and decision making mechanisms in individuals brains. These substances can cause dangerous consequences in the lives of individuals by causing addiction and, on the other hand, by stimulating or depressing the central nervous system, causing mood, mental state, behavioral and motor function disorders. Caffeine, hallucinogens, lysergic acid diethylamide (LSD), inhalants, nicotine, phencyclidine, sedatives, hypnotics, anxiolytics, anabolic steroids, nitrous oxide are among the addictive substances (1 ,2). The incidence of psychiatric disorders in patients with substance use disorders is 2.7 times higher. It has been reported that 70-75% of individuals with substance use disorders are accompanied by at least one psychiatric disorder (2,3). It is also known that substance abuse is more common in psychiatric disorders. In a study conducted in Turkey psychoactive substance use in schizophrenia 3.2%, while bipolar disorder is reported to be 3.5%. In the same study, 39% of the patients who received substance abuse and inpatient treatment received psychotic disorder and 23% received bipolar disorder (4).

Very common psychotic disorder or comorbid condition among substance use related disorders is clinically important. One of the biggest challenges faced by clinicians in this case is the primary-secondary distinction (5). In this study, psychoactive substance use and psychosis association and primary-secondary distinction are discussed through two case studies.