Buprenorphine is a semi-synthetic opioid derived from thebaine. It is used for analgesic effect and opioid substitution therapy. In Turkey, buprenorphine and naloxone combination (Suboxone®) has been used in opioid substitution therapy since 2010. In this paper respiratory depression arising after buprenorphine use together with benzodiazepine will be told and possible mechanisms of this interaction will be discussed.

Naltrexone subcutaneous implants are among the new alternatives in the treatment of alcohol and opioid addictions in our country.Nausea, vomitting, headache, skin rash, depression, anxiety and loss of energy are side effects reported in the use of naltrexone. This paper discusses a case of itching and skin eruptions following the application of naltrexone subcutaneous implant.